Intended for US healthcare professionals only.

Intended for US healthcare professionals only.

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Have Your Patients Reached the Tipping Point®?

Determine FIB-4, NFS, and APRI scores using the calculators below. You can calculate any one of three simple scores to assess the presence of Advanced Fibrosis.

 

NIT Calculators*

Choose which score you would like to calculate, then fill in the required information.

years

U/L

Normal: 1-40

U/L

Normal: 1-35

x 109/L

Normal: 150-350

†Use with caution in patients <35 or >65 years old, as the score has been shown to be less reliable in these patients

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FIB-4

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Additional Information

<1.3
fib advanced fibrosis absence upper limit marker
≥2.67
fib advanced fibrosis indeterminate upper limit marker

Absence of
Advanced Fibrosis

Sensitivity of 82%

18% of patients with
Advanced Fibrosis
are missed

Indeterminate Zone

Consider the use of a
second NIT

Presence of
Advanced Fibrosis

Specificity of 93%

7% of patients are wrongly
diagnosed with Advanced
Fibrosis

Next Steps

Record Your Results

  1. Write down or print your patient's results.
  2. Perform a second NIT. (i.e. an imaging test or proprietary serum test.)
  3. Recommend lifestyle modifications.
  4. Monitor your patient.
print background Print Results
years

U/L

Normal: 1-40

U/L

Normal: 1-35

kg/m2

Normal: 20-25

g/dL

Normal: 3.5-5.5

x 109/L

Normal: 150-350

†Use with caution in patients <35 or >65 years old, as the score has been shown to be less reliable in these patients

{{nfsResultMessage}}  

NFS

{{nfsResult}}

Additional Information

<-1.455
nfs advanced fibrosis absence upper limit marker
≥0.676
fib advanced fibrosis indeterminate upper limit marker

Absence of
Advanced Fibrosis

Sensitivity of 89%

11% of patients with Advanced Fibrosis are missed

Indeterminate Zone

Consider the use of a
second NIT

Presence of
Advanced Fibrosis

Specificity of 89%

11% of patients are wrongly diagnosed with Advanced Fibrosis

print background

Next Steps

Record Your Results

  1. Write down or print your patient's results.
  2. Perform a second NIT. (i.e. an imaging test or proprietary serum test.)
  3. Recommend lifestyle modifications.
  4. Monitor your patient.
Print Results

†Use with caution in patients <35 or >65 years old, as the score has been shown to be less reliable in these patients

No information is collected, stored or shared. All information remains local to the test and is deleted immediately after.

AST, aspartate aminotransferase: ALT, alanine aminotransferase: U/L, units per liter

No information is collected, stored or shared. All information remains local to the test and is deleted immediately after.

AST, aspartate aminotransferase; ALT, alanine aminotransferase; U/L, units per liter; BMI, body mass index.

*Calculator is provided for educational and illustrative purposes only. Intercept cannot warrant the accuracy or completeness of information that this calculator provides. Intercept does not engage in the practice of medicine, and this calculator is not a substitute for appropriate medical education and training or for the exercise of independent medical judgment. Healthcare providers are advised to consult the product labeling, and any appropriate research literature before implementing any new treatments or techniques. Intercept expressly disclaims all liability to any person in respect of all matters and all actions taken or not taken based on any information contained herein.

Advanced Fibrosis
Due to NASHNONINVASIVE TESTS FOR
IDENTIFYING ADVANCED FIBROSISIdentifying NASH
Without a Biopsy

 

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NASH, nonalcoholic steatohepatitis; NITs, noninvasive tests; NAFLD, nonalcoholic fatty liver disease; FIB-4, fibrosis-4; F0–F2, stage 0–2 fibrosis; F2, stage 2 fibrosis; F3, stage 3 fibrosis; F4, stage 4 fibrosis; NFS, NAFLD fibrosis score; APRI, aspartate aminotransferase/platelet ratio index; US, United States.

References: 1. Alkhouri N, McCullough AJ. Noninvasive diagnosis of NASH and liver fibrosis within the spectrum of NAFLD. Gastroenterol Hepatol (NY). 2012;8(10):661–668. 2. Anstee QM, Lawitz EJ, Alkhouri N, et al. Noninvasive tests accurately identify advanced fibrosis due to NASH: baseline data from the STELLAR trials. Hepatology. 2019;70(5):1521-1530.

US-PP-NAS-0679 09/20